דף נחיתה

ACTIVE-RCT-I	ACTIVE-RCT-II
Mild-moderate disease activity (wPCDAI 20-57.5 or CDAI 200-450) or milder disease (wPCDAI 12.5-57.5 or CDAI 150-450)	Clinical remission or at most minimal symptoms (wPCDAI<20/ CDAI<200)
Ages 6-24	Ages 6-40
Disease duration: less than a year	Disease duration <3 years
	MINI≥8 points (FC>600 OR FC>300 and elevated CRP/ESR)
No drugs or maintenance stable treatment IMM/5ASA	No drugs or maintenance stable treatment IMM/5ASA or first biologic

Fibrostenotic or penetrating phenotype.
Fistulizing perianal disease which is not in complete remission.
“UC-like” isolated Crohn’s colitis.
Prior failure of exclusive enteral nutrition or any other dietary intervention, for any reason.
The use of steroids, budesonide or antibiotics prescribed to treat the CD in the recent month.
Any formula feed during the last month.
Prior intestinal resection.
Pregnancy.
Celiac disease.
For ACTIVE-RCT-I: any prior or concurrent biologic therapy; for MH-RCT-II: any prior or concurrent biologic therapy other than one first biologic.

Study PI: Prof. Dan Turner | [email protected]

Study Management: Gili Focht | [email protected] | Luba Plotkin | [email protected]